Choose your mutation, select the amino acid to mutate to, and how many flanking codons you're willing to modify (while maintaining amino acid, of course!)

Pick the enzymes you want to use. Use a handy utility menu to pick, say, commercially available 6-cutters.

After pushing "Find Candidates", see your results! Save your results to a file or print them. Or, go back, change the settings and try again! (Notice how all changed nucleic acids are colored red.)